Course: Pharmacochemistry

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Course title Pharmacochemistry
Course code UOCHT/C840
Organizational form of instruction Lecture
Level of course Bachelor
Year of study 3
Semester Winter
Number of ECTS credits 5
Language of instruction Czech
Status of course Compulsory-optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Sedlák Miloš, prof. Ing. DrSc.
Course content
Object of pharmaceutical chemistry, basic notions - pharmacology, pharmacognosy, galenic pharmacy, medicinal drug, form of medicinal drug. Basic principles of general pharmacology - way of administration, fate of drug in organism: absorption, transport and distribution, metabolism (bio-transformations - oxidation, reduction, hydrolysis, conjugation, non-enzymatic transformations), excretion. Effects of medicinal drugs - specific and non-specific effect - relationships between structure and effect. Problems of research and development of new pharmaceuticals. European and Czech Pharmacopoeias, classification of drugs from pharmacological standpoint. General anaesthetics - mechanism of action. Syntheses of fluorine-containing inhalation anaesthetics (halothane), general intravenous anaesthetics (thiopental). Hypnotics and sedatives - effect and application. Syntheses of selected hypnotics of the 1st to 3rd generations.:

Learning activities and teaching methods
Monologic (reading, lecture, briefing), Dialogic (discussion, interview, brainstorming)
Learning outcomes
Strategy for Organic Drug Synthesis and Design.
Absolvents are Able Applicate Strategy for Organic Drug Synthesis and Design.
Prerequisites
KOCH/C008 - Organic chemistry I KFCH/C014 - Principles of Physical Chemistry
UOCHT/C008 and UOCHT/C511

Assessment methods and criteria
Oral examination, Written examination

Understanding and active knowledge of Basic organic synthesis.
Recommended literature
  • Holý A.:. PRINCIPY BIORGANICKÉ CHEMIE VE VÝVOJI ANTIVIROTIK A CYTOSTATIK, Univerzita Palackého V Olomouci, Olomouc 2004, [ISBN 80-244-0855-4]..
  • Paleček J., Hampl F.:. FARMAKOCHEMIE, skripta 2.vydání, VŠCHT Praha 2002,[ISBN 80-7080-495-5]..


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Chemical Technology Chemistry and Technical Chemistry (2015) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Chemistry and Technical Chemistry (2014) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Farmacochemistry and Medicinal Materials (2016) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Farmacochemistry and Medicinal Materials (2015) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Chemistry and Technical Chemistry (2013) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Chemistry and Technical Chemistry (2016) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Farmacochemistry and Medicinal Materials (2014) Engineering chemistry and chemistry of silicates 3 Winter
Faculty of Chemical Technology Farmacochemistry and Medicinal Materials (2013) Engineering chemistry and chemistry of silicates 3 Winter